CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrofolate Reductase, subunit A
Functional Family Dihydrofolate reductase

Enzyme Information

1.5.1.3
Dihydrofolate reductase.
based on mapping to UniProt P00375
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

P00375
DYR_MOUSE
Mus musculus
Dihydrofolate reductase

PDB Structure

PDB 3D80
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural analysis of a holoenzyme complex of mouse dihydrofolate reductase with NADPH and a ternary complex with the potent and selective inhibitor 2,4-diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine.
Cody, V., Pace, J., Rosowsky, A.
Acta Crystallogr.,Sect.D