CATH Classification

Domain Context

CATH Clusters

Superfamily Pantoate-beta-alanine ligase, C-terminal domain
Functional Family Pantothenate synthetase

Enzyme Information

6.3.2.1
Pantoate--beta-alanine ligase (AMP-forming).
based on mapping to UniProt P9WIL5
ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.

UniProtKB Entries (1)

P9WIL5
PANC_MYCTU
Mycobacterium tuberculosis H37Rv
Pantothenate synthetase

PDB Structure

PDB 3COY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate.
Ciulli, A., Scott, D.E., Ando, M., Reyes, F., Saldanha, S.A., Tuck, K.L., Chirgadze, D.Y., Blundell, T.L., Abell, C.
Chembiochem