CATH Domain 3c3uA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.100	NADP-dependent oxidoreductase domain

Domain Context

CATH Clusters

Superfamily	NADP-dependent oxidoreductase domain
Functional Family	Aldo-keto reductase family 1 member C3

Enzyme Information

1.3.1.20	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. based on mapping to UniProt Q04828 Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH.
1.1.1.-	With NAD(+) or NADP(+) as acceptor. based on mapping to UniProt Q04828
1.1.1.149	20-alpha-hydroxysteroid dehydrogenase. based on mapping to UniProt Q04828 17-alpha,20-alpha-dihydroxypregn-4-en-3-one + NAD(P)(+) = 17-alpha- hydroxyprogesterone + NAD(P)H. -!- Re-specific with respect to NAD(P)(+) (cf. EC 1.1.1.62).
1.1.1.112	Indanol dehydrogenase. based on mapping to UniProt Q04828 Indan-1-ol + NAD(P)(+) = indanone + NAD(P)H. -!- 3(20)-alpha-hydroxysteroids are also oxidized, more slowly.

UniProtKB Entries (1)

AK1C1_HUMAN

Homo sapiens

Aldo-keto reductase family 1 member C1

PDB Structure

PDB	3C3U
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Selectivity determinants of inhibitor binding to human 20alpha-hydroxysteroid dehydrogenase: crystal structure of the enzyme in ternary complex with coenzyme and the potent inhibitor 3,5-dichlorosalicylic acid Dhagat, U., Endo, S., Sumii, R., Hara, A., El-Kabbani, O. J.Med.Chem.