CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleotide cyclase
Functional Family Adenylate cyclase

Enzyme Information

4.6.1.1
Adenylate cyclase.
based on mapping to UniProt P26769
ATP = 3',5'-cyclic AMP + diphosphate.
-!- Also acts on dATP to form 3',5'-cyclic dAMP. -!- Requires pyruvate. -!- Activated by NAD(+) in presence of EC 2.4.2.31.

UniProtKB Entries (3)

P26769
ADCY2_RAT
Rattus norvegicus
Adenylate cyclase type 2
P30803
ADCY5_CANLF
Canis lupus familiaris
Adenylate cyclase type 5
P04896
GNAS2_BOVIN
Bos taurus
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

PDB Structure

PDB 3C14
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for inhibition of mammalian adenylyl cyclase by calcium.
Mou, T.C., Masada, N., Cooper, D.M., Sprang, S.R.
Biochemistry