CATH Domain 3c0zC00
|3.40.800||Arginase; Chain A|
|3.40.800.20||Histone deacetylase domain|
|Superfamily||Histone deacetylase domain|
|Functional Family||Histone deacetylase|
based on mapping to UniProt Q8WUI4
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
-!- A class of enzymes that remove acetyl groups from N(6)-acetyl-lysine residues on a histone. -!- The reaction of this enzyme is opposite to that of EC 18.104.22.168. -!- Histone deacetylases (HDACs) can be organized into three classes depending on sequence similarity and domain organization. -!- Histone acetylation plays an important role in regulation of gene expression. -!- In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation. -!- May be identical to EC 22.214.171.124.
UniProtKB Entries (1)
Histone deacetylase 7
Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.