CATH Classification

Domain Context

CATH Clusters

Superfamily Histone deacetylase domain
Functional Family Histone deacetylase

Enzyme Information
Histone deacetylase.
based on mapping to UniProt Q8WUI4
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
-!- A class of enzymes that remove acetyl groups from N(6)-acetyl-lysine residues on a histone. -!- The reaction of this enzyme is opposite to that of EC -!- Histone deacetylases (HDACs) can be organized into three classes depending on sequence similarity and domain organization. -!- Histone acetylation plays an important role in regulation of gene expression. -!- In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation. -!- May be identical to EC

UniProtKB Entries (1)

Homo sapiens
Histone deacetylase 7

PDB Structure

External Links
Organism Escherichia
Primary Citation
Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.
Schuetz, A., Min, J., Allali-Hassani, A., Schapira, M., Shuen, M., Loppnau, P., Mazitschek, R., Kwiatkowski, N.P., Lewis, T.A., Maglathin, R.L., McLean, T.H., Bochkarev, A., Plotnikov, A.N., Vedadi, M., Arrowsmith, C.H.