CATH Classification

Domain Context

CATH Clusters

Superfamily Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family

Enzyme Information

2.1.1.45
Thymidylate synthase.
based on mapping to UniProt P00469
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

P00469
TYSY_LACCA
Lactobacillus casei
Thymidylate synthase

PDB Structure

PDB 3C0A
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening
Mangani, S., Cancian, L., Leone, R., Pozzi, C., Lazzari, S., Luciani, R., Ferrari, S., Costi, M.P.
J.Med.Chem.