CATH Domain 3busB00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.150	Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily	Vaccinia Virus protein VP39
Functional Family

Enzyme Information

2.1.1.164

Demethylrebeccamycin-D-glucose O-methyltransferase.

based on mapping to UniProt Q8KZ94

4'-demethylrebeccamycin + S-adenosyl-L-methionine = rebeccamycin + S-adenosyl-L-homocysteine.

-!- Catalyzes the last step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. -!- The enzyme is able to use a wide variety substrates, tolerating variation on the imide heterocycle, deoxygenation of the sugar moiety, and even indolocarbazole glycoside anomers.

UniProtKB Entries (1)

Q8KZ94

REBMT_NOCAE

Lechevalieria aerocolonigenes

Demethylrebeccamycin-D-glucose O-methyltransferase

PDB Structure

PDB	3BUS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure and mechanism of the rebeccamycin sugar 4'-O-methyltransferase RebM. Singh, S., McCoy, J.G., Zhang, C., Bingman, C.A., Phillips Jr., G.N., Thorson, J.S. J.Biol.Chem.