CATH Classification

Domain Context

CATH Clusters

Superfamily 3.90.660.10
Functional Family

Enzyme Information
Non-specific polyamine oxidase.
based on mapping to UniProt P50264
(1) Spermine + O(2) + H(2)O = spermidine + 3-aminopropanal + H(2)O(2). (2) Spermidine + O(2) + H(2)O = putrescine + 3-aminopropanal + H(2)O(2). (3) N(1)-acetylspermine + O(2) + H(2)O = spermidine + 3-acetamidopropanal + H(2)O(2). (4) N(1)-acetylspermidine + O(2) + H(2)O = putrescine + 3-acetamidopropanal + H(2)O(2).
-!- The non-specific polyamine oxidases may differ from each other considerably. -!- The enzyme from Saccharomyces cerevisiae shows a rather broad specificity and also oxidizes N(8)-acetylspermidine. -!- The enzyme from Ascaris suum shows high activity with spermine and spermidine, but also oxidizes norspermine. -!- The enzyme from Arabidopsis thaliana shows high activity with spermidine, but also oxidizes other polyamines. -!- The specific polyamine oxidases are classified as EC, EC, EC and EC -!- Formerly EC, EC 1.5.3.n1, EC 1.5.3.n2 and EC 1.5.3.n4.

UniProtKB Entries (1)

Saccharomyces cerevisiae S288C
Polyamine oxidase FMS1

PDB Structure

External Links
Organism Escherichia
Primary Citation
Structural basis of the substrate stereospecificity of FMS1.
Huang, Q., Hao, Q.
To Be Published