CATH Classification

Domain Context

CATH Clusters

Superfamily Luciferase-like domain
Functional Family F420-dependent glucose-6-phosphate dehydrogenase

Enzyme Information

1.1.98.2
Glucose-6-phosphate dehydrogenase (coenzyme-F420).
based on mapping to UniProt P9WNE1
D-glucose 6-phosphate + oxidized coenzyme F420 = D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420.
-!- The enzyme is very specific for D-glucose 6-phosphate. -!- No activity with NAD(+), NADP(+), flavin adenine dinucleotide and flavin mononucleotide. -!- Formerly EC 1.1.99.34.

UniProtKB Entries (1)

P9WNE1
FGD_MYCTU
Mycobacterium tuberculosis H37Rv
F420-dependent glucose-6-phosphate dehydrogenase

PDB Structure

PDB 3B4Y
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding
Bashiri, G., Squire, C.J., Moreland, N.J., Baker, E.N.
J.Biol.Chem.