CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.718 | Isopropylmalate Dehydrogenase |
|
3.40.718.10 | Isopropylmalate Dehydrogenase |
Domain Context
CATH Clusters
| Superfamily | Isopropylmalate Dehydrogenase |
| Functional Family | Homoisocitrate dehydrogenase |
Enzyme Information
| 1.1.1.87 |
Homoisocitrate dehydrogenase.
based on mapping to UniProt Q5SIJ1
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD(+) = 2-oxoadipate + CO(2) + NADH.
-!- Forms part of the lysine biosynthesis pathway in fungi. -!- Formerly EC 1.1.1.155.
|
UniProtKB Entries (1)
| Q5SIJ1 |
HICDH_THET8
Thermus thermophilus HB8
Homoisocitrate dehydrogenase
|
PDB Structure
| PDB | 3ASJ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of Thermus thermophilus homoisocitrate dehydrogenase in complex with a designed inhibitor
J.Biochem.
|
