CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha-helical ferredoxin
Functional Family Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Enzyme Information
Succinate dehydrogenase (quinone).
based on mapping to UniProt Q007T0
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. -!- It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). -!- In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. -!- Cf. EC

UniProtKB Entries (1)

Sus scrofa
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

PDB Structure

External Links
Primary Citation
Crystal structure of porcine heart mitochondrial complex II bound with N-Phenyl-2-(trifluoromethyl)-benzamide
Harada, S., Sasaki, T., Shindo, M., Kido, Y., Inaoka, D.K., Omori, J., Osanai, A., Sakamoto, K., Mao, J., Matsuoka, S., Inoue, M., Honma, T., Tanaka, A., Kita, K.
to be published