CATH Classification

Domain Context

CATH Clusters

Superfamily Bira Bifunctional Protein; Domain 2
Functional Family Serine--tRNA ligase

Enzyme Information

6.1.1.11
Serine--tRNA ligase.
based on mapping to UniProt O58441
(1) ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). (2) ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec).
-!- This enzyme also recognizes tRNA(Sec), the special tRNA for selenocysteine, and catalyzes the formation of L-seryl-tRNA(Sec), the substrate for EC 2.9.1.1.

UniProtKB Entries (1)

O58441
SYS_PYRHO
Pyrococcus horikoshii OT3
Serine--tRNA ligase

PDB Structure

PDB 2ZR2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystallographic and mutational studies of seryl-tRNA synthetase from the archaeon Pyrococcus horikoshii.
Itoh, Y., Sekine, S., Kuroishi, C., Terada, T., Shirouzu, M., Kuramitsu, S., Yokoyama, S.
Rna Biol.