CATH Domain 2zmfA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.450	Beta-Lactamase
	3.30.450.40	GAF domain

Domain Context

CATH Clusters

Superfamily	3.30.450.40
Functional Family	Phosphodiesterase

Enzyme Information

3.1.4.17	3',5'-cyclic-nucleotide phosphodiesterase. based on mapping to UniProt Q9Y233 Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate. -!- Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.
3.1.4.35	3',5'-cyclic-GMP phosphodiesterase. based on mapping to UniProt Q9Y233 Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

UniProtKB Entries (1)

PDE10_HUMAN

Homo sapiens

CAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

PDB Structure

PDB	2ZMF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of the GAF-B Domain from Human Phosphodiesterase 10A Complexed with Its Ligand, cAMP Handa, N., Mizohata, E., Kishishita, S., Toyama, M., Morita, S., Uchikubo-Kamo, T., Akasaka, R., Omori, K., Kotera, J., Terada, T., Shirouzu, M., Yokoyama, S. J.Biol.Chem.