CATH Classification

Domain Context

CATH Clusters

Superfamily Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Functional Family

Enzyme Information

2.4.1.226
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase.
based on mapping to UniProt Q8L0V4
(1) UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D- GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA- (1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine. (2) UDP-alpha-D-glucuronate + [protein]-3-O-((beta-D-GalNAc-(1->4)-beta- D-GlcA-(1->3))(n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal- (1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3- O-(beta-D-GlcA-(1->3)-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3))(n)-beta- D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)- beta-D-Xyl)-L-serine.
-!- Involved in the biosynthesis of chondroitin and dermatan sulfate. -!- The human chondroitin synthetase is a bifunctional glycosyltransferase, which also has the EC 2.4.1.175 activity required for the synthesis of the chondroitin sulfate disaccharide repeats. -!- Similar chondroitin synthase 'copolymerases' can be found in Pasteurella multocida and Escherichia coli. -!- There is also another human protein with apparently only the 3-beta- glucuronosyltransferase activity.
2.4.1.175
Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N- acetylgalactosaminyltransferase.
based on mapping to UniProt Q8L0V4
(1) UDP-N-acetyl-alpha-D-galactosamine + [protein]-3-O-(beta-D-GlcA- (1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D- Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-(beta-D-GalNAc- (1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D- Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine. (2) UDP-N-acetyl-alpha-D-galactosamine + [protein]-3-O-(beta-D-GlcA- (1->3)-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3))(n)-beta-D-GalNAc-(1->4)- beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L- serine = UDP + [protein]-3-O-((beta-D-GalNAc-(1->4)-beta-D-GlcA- (1->3))(n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)- beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine.
-!- Involved in the biosynthesis of chondroitin sulfate. -!- The human form of this enzyme is a bifunctional glycosyltransferase, which also has the EC 2.4.1.226 activity required for the synthesis of the chondroitin sulfate disaccharide repeats. -!- Similar chondroitin synthase 'copolymerases' can be found in Pasteurella multocida and Escherichia coli.

UniProtKB Entries (1)

Q8L0V4
CHS_ECOLX
Escherichia coli
Chondroitin synthase

PDB Structure

PDB 2Z86
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of chondroitin polymerase from Escherichia coli K4.
Osawa, T., Sugiura, N., Shimada, H., Hirooka, R., Tsuji, A., Shirakawa, T., Fukuyama, K., Kimura, M., Kimata, K., Kakuta, Y.
Biochem. Biophys. Res. Commun.