CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.600 | Farnesyl Diphosphate Synthase |
|
1.10.600.10 | Farnesyl Diphosphate Synthase |
Domain Context
CATH Clusters
| Superfamily | Farnesyl Diphosphate Synthase |
| Functional Family | Geranylgeranyl pyrophosphate synthase |
Enzyme Information
| 2.5.1.- |
Transferring alkyl or aryl groups, other than methyl groups.
based on mapping to UniProt Q12051
|
| 2.5.1.10 |
(2E,6E)-farnesyl diphosphate synthase.
based on mapping to UniProt Q12051
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)- farnesyl diphosphate.
-!- Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate. -!- The enzyme will not accept larger prenyl diphosphates as efficient donors.
|
| 2.5.1.29 |
Geranylgeranyl diphosphate synthase.
based on mapping to UniProt Q12051
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
-!- Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors.
|
| 2.5.1.1 |
Dimethylallyltranstransferase.
based on mapping to UniProt Q12051
Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
-!- Will not accept larger prenyl diphosphates as efficient donors.
|
UniProtKB Entries (1)
| Q12051 |
GGPPS_YEAST
Saccharomyces cerevisiae S288C
Geranylgeranyl pyrophosphate synthase
|
PDB Structure
| PDB | 2Z78 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
J.Med.Chem.
|
