CATH Classification

Domain Context

CATH Clusters

Superfamily Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Functional Family UDP-N-acetylglucosamine diphosphorylase 2

Enzyme Information

2.7.7.23
UDP-N-acetylglucosamine diphosphorylase.
based on mapping to UniProt O74933
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + UDP-N- acetyl-alpha-D-glucosamine.
-!- Part of the pathway for acetamido sugar biosynthesis in bacteria and archaea. -!- The enzyme from several bacteria (e.g., Escherichia coli, Bacillus subtilis and Haemophilus influenzae) has been shown to be bifunctional and also to possess the activity of EC 2.3.1.157. -!- The enzyme from plants and animals is also active toward N-acetyl- alpha-D-galactosamine 1-phosphate (cf. EC 2.7.7.83), while the bacterial enzyme shows low activity toward that substrate.

UniProtKB Entries (1)

O74933
UAP1_CANAX
Candida albicans
UDP-N-acetylglucosamine pyrophosphorylase

PDB Structure

PDB 2YQS
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of Uridine-diphospho-N-acetylglucosamine Pyrophosphorylase from Candida albicans and Catalytic Reaction Mechanism
Maruyama, D., Nishitani, Y., Nonaka, T., Kita, A., Fukami, T.A., Mio, T., Yamada-Okabe, H., Yamada-Okabe, T., Miki, K.
J.Biol.Chem.