CATH Domain 2y92A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.10140	Toll/interleukin-1 receptor homology (TIR) domain

Domain Context

CATH Clusters

Superfamily	Toll/interleukin-1 receptor homology (TIR) domain
Functional Family	Toll/interleukin-1 receptor domain-containing adapter protein

Enzyme Information

UniProtKB Entries (1)

TIRAP_HUMAN

Homo sapiens

Toll/interleukin-1 receptor domain-containing adapter protein

PDB Structure

PDB	2Y92
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of Toll-Like Receptor Adaptor Mal/Tirap Reveals the Molecular Basis for Signal Transduction and Disease Protection. Valkov, E., Stamp, A., Dimaio, F., Baker, D., Verstak, B., Roversi, P., Kellie, S., Sweet, M.J., Mansell, A., Gay, N.J., Martin, J.L., Kobe, B. Proc.Natl.Acad.Sci.USA