CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.450.40
Functional Family Amine oxidase

Enzyme Information
Primary-amine oxidase.
based on mapping to UniProt Q16853
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).
-!- A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1). -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
Membrane primary amine oxidase

PDB Structure

PDB 2Y74
External Links
Primary Citation
Identification of Two Imidazole Binding Sites and Key Residues for Substrate Specificity in Human Primary Amine Oxidase Aoc3.
Elovaara, H., Kidron, H., Parkash, V., Nymalm, Y., Bligt, E., Ollikka, P., Smith, D.J., Pihlavisto, M., Salmi, M., Jalkanen, S., Salminen, T.A.