CATH Domain 2xzzA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.10	Immunoglobulins

Domain Context

CATH Clusters

Superfamily	Immunoglobulins
Functional Family	Protein-glutamine gamma-glutamyltransferase 2

Enzyme Information

2.3.2.13

Protein-glutamine gamma-glutamyltransferase.

based on mapping to UniProt P22735

A protein-L-glutamine + a protein-L-lysine = a protein with an N(6)- (gamma-glutamyl)-L-lysine cross-link + NH(3).

-!- The gamma-carboxymide groups of peptide-bound glutamine residues act as acyl donors, and the 6-amino-groups of protein- and peptide-bound lysine residues act as acceptors, to give intra- and inter-molecular N(6)-(5-glutamyl)lysine cross-links.

UniProtKB Entries (1)

P22735

TGM1_HUMAN

Homo sapiens

Protein-glutamine gamma-glutamyltransferase K

PDB Structure

PDB	2XZZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of the Human Transglutaminase 1 Beta-Barrel Domain Vollmar, M., Krysztofinska, E., Krojer, T., Yue, W.W., Cooper, C., Kavanagh, K., Allerston, C., Chaikuad, A., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U. To be Published