CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.58.1370
Functional Family lysine-specific demethylase 6A isoform X2

Enzyme Information

1.14.11.-
With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.
based on mapping to UniProt O15054

UniProtKB Entries (1)

O15054
KDM6B_HUMAN
Homo sapiens
Lysine-specific demethylase 6B

PDB Structure

PDB 2XUE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A Selective Jumonji H3K27 Demethylase Inhibitor Modulates the Proinflammatory Macrophage Response
Kruidenier, L., Chung, C., Cheng, Z., Liddle, J., Che, K., Joberty, G., Bantscheff, M., Bountra, C., Bridges, A., Diallo, H., Eberhard, D., Hutchinson, S., Jones, E., Katso, R., Leveridge, M., Mander, P.K., Mosley, J., Ramirez-Molina, C., Rowland, P., Schofield, C.J., Sheppard, R.J., Smith, J.E., Swales, C., Tanner, R., Thomas, P., Tumber, A., Drewes, G., Oppermann, U., Patel, D.J., Lee, K., Wilson, D.M.
Nature