CATH Classification

Domain Context

CATH Clusters

Superfamily Mur ligase, C-terminal domain
Functional Family UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase

Enzyme Information

6.3.2.13
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase.
based on mapping to UniProt P9WJL3
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + meso-2,6- diaminoheptanedioate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L- alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate.
-!- Involved in the synthesis of a cell-wall peptide. -!- This enzyme adds diaminopimelate in Gram-negative organisms and in some Gram-positive organisms; in others EC 6.3.2.7 adds lysine instead. -!- It is the amino group of the L-center of the diaminopimelate that is acylated.

UniProtKB Entries (1)

P9WJL3
MURE_MYCTU
Mycobacterium tuberculosis H37Rv
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase

PDB Structure

PDB 2XJA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Essential Residues for the Enzyme Activity of ATP-Dependent Mure Ligase from Mycobacterium Tuberculosis.
Basavannacharya, C., Moody, P.R., Munshi, T., Cronin, N., Keep, N.H., Bhakta, S.
Protein Cell