CATH Domain 2x7fD02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	TRAF2 and NCK-interacting protein kinase isoform 4

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt Q9UKE5

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q9UKE5

TNIK_HUMAN

Homo sapiens

TRAF2 and NCK-interacting protein kinase

PDB Structure

PDB	2X7F
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of the Kinase Domain of Human Traf2- and Nck-Interacting Kinase with Wee1Chk1 Inhibitor Vollmar, M., Alfano, I., Shrestha, B., Bray, J., Muniz, J.R.C., Roos, A., Filippakopoulos, P., Burgess-Brown, N., Ugochukwu, E., Gileadi, O., Phillips, C., Mahajan, P., Pike, A.C.W., Fedorov, O., Chaikuad, A., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S. To be Published

Network disruptions