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1 keywords

CATH Domain 2wo7A00

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.60 Sandwich
Topology 2.60.120 Jelly Rolls
Homologous Superfamily 2.60.120.330 B-lactam Antibiotic, Isopenicillin N Synthase; Chain

Domain Context

CATH Clusters

Superfamily B-lactam Antibiotic, Isopenicillin N Synthase; Chain
Functional Family Isopenicillin N synthase

Enzyme Information

1.21.3.1
Isopenicillin-N synthase.
based on mapping to UniProt P05326
N-((5S)-5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + O(2) = isopenicillin N + 2 H(2)O.
-!- Forms part of the penicillin biosynthesis pathway.

UniProtKB Entries (1)

P05326
IPNS_EMENI
Aspergillus nidulans FGSC A4
Isopenicillin N synthase

PDB Structure

PDB 2WO7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystallographic Studies on the Binding of Selectively Deuterated Lld- and Lll-Substrate Epimers by Isopenicillin N Synthase.
Ge, W., Clifton, I.J., Stok, J.E., Adlington, R.M., Baldwin, J.E., Rutledge, P.J.
Biochem.Biophys.Res.Commun.
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