CATH Domain 2vsuE01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.226	2-enoyl-CoA Hydratase; Chain A, domain 1
	3.90.226.10	2-enoyl-CoA Hydratase; Chain A, domain 1

Domain Context

CATH Clusters

Superfamily	2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family	p-hydroxycinnamoyl CoA hydratase/lyase

Enzyme Information

4.2.1.101	Trans-feruloyl-CoA hydratase. based on mapping to UniProt O69762 4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA = feruloyl-CoA + H(2)O.
4.1.2.41	Vanillin synthase. based on mapping to UniProt O69762 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = vanillin + acetyl- CoA. -!- Involved, together with EC 4.2.1.101 in the production of vanillin from trans-ferulic acid. -!- Vanillin is converted to vanillate by EC 1.2.1.67.

UniProtKB Entries (1)

HCHL_PSEFL

Pseudomonas fluorescens

Hydroxycinnamoyl-CoA hydratase-lyase

PDB Structure

PDB	2VSU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A Ternary Complex of Hydroxycinnamoyl-Coa Hydratase-Lyase (Hchl) with Acetyl-Coa and Vanillin Gives Insights Into Substrate Specificity and Mechanism. Bennett, J.P., Bertin, L., Moulton, B., Fairlamb, I.J.S., Brzozowski, A.M., Walton, N.J., Grogan, G. Biochem.J.