CATH Classification

Domain Context

CATH Clusters

Superfamily Protein tyrosine phosphatase superfamily
Functional Family Tyrosine-protein phosphatase non-receptor type 1

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt P18031
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

P18031
PTN1_HUMAN
Homo sapiens
Tyrosine-protein phosphatase non-receptor type 1

PDB Structure

PDB 2VEY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Isothiazolidinone Inhibitors of Ptp1B Containing Imidazoles and Imidazolines
Douty, B., Wayland, B., Ala, P.J., Bower, M.J., Pruitt, J., Bostrom, L., Wei, M., Klabe, R., Gonneville, L., Wynn, R., Burn, T.C., Liu, P.C.C., Combs, A.P., Yue, E.W.
Bioorg.Med.Chem.Lett.