CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Iridoid synthase |
Enzyme Information
| 1.3.1.3 |
Delta(4)-3-oxosteroid 5-beta-reductase.
based on mapping to UniProt Q6PQJ9
(1) 5-beta-cholestan-3-one + NADP(+) = cholest-4-en-3-one + NADPH. (2) 17,21-dihydroxy-5-beta-pregnane-3,11,20-trione + NADP(+) = cortisone + NADPH.
-!- The enzyme from human efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent. -!- The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3- one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates.
|
UniProtKB Entries (1)
| Q6PQJ9 |
5BPOR_DIGLA
Digitalis lanata
3-oxo-Delta(4,5)-steroid 5-beta-reductase
|
PDB Structure
| PDB | 2V6F |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The Crystal Structure of Progesterone 5{Beta}-Reductase from Digitalis Lanata Defines a Novel Class of Short Chain Dehydrogenases/Reductases.
J.Biol.Chem.
|
