CATH Classification

Domain Context

CATH Clusters

Superfamily 3.90.660.10
Functional Family Amine oxidase [flavin-containing] B

Enzyme Information
Monoamine oxidase.
based on mapping to UniProt P27338
RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2).
-!- Catalyzes the oxidative deamination of neurotransmitters and biogenic amines. -!- Acts on primary amines, and also on some secondary and tertiary amines. -!- It differs from EC, as it can oxidize secondary and tertiary amines but not methylamine. -!- Inhibited by acetylenic compounds such as chlorgyline, 1-deprenyl and pargyline but, unlike EC and EC, it is not inhibited by semicarbazide. -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
Amine oxidase [flavin-containing] B

PDB Structure

PDB 2V60
External Links
Primary Citation
Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs.
Binda, C., Wang, J., Pisani, L., Caccia, C., Carotti, A., Salvati, P., Edmondson, D.E., Mattevi, A.