CATH Classification

Domain Context

CATH Clusters

Superfamily Acyl-CoA dehydrogenase/oxidase, N-terminal domain
Functional Family Very long-chain-specific acyl-CoA dehydrogenase, mitochondrial

Enzyme Information
Very-long-chain acyl-CoA dehydrogenase.
based on mapping to UniProt P49748
A very-long-chain acyl-CoA + electron-transfer flavoprotein = a very- long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.
-!- One of several enzymes that catalyze the first step in fatty acids beta-oxidation. -!- The enzyme is most active toward long-chain acyl-CoAs such as C(14), C(16) and C(18), but is also active with very-long-chain acyl-CoAs up to 24 carbons. -!- It shows no activity for substrates of less than 12 carbons. -!- It's specific activity toward palmitoyl-CoA is more than 10-fold that of the long-chain acyl-CoA dehydrogenase. -!- cf. EC, EC and EC -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

PDB Structure

External Links
Primary Citation
Crystal Structure of Human Very Long Chain Acyl- Coa Dehydrogenase (Acadvl)
Pike, A.C.W., Hozjan, V., Smee, C., Berridge, G., Burgess, N., Salah, E., Bunkoczi, G., Uppenberg, J., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Oppermann, U.
To be Published