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1 keywords

CATH Domain 2rmxA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.505 SHC Adaptor Protein
Homologous Superfamily 3.30.505.10 SH2 domain

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family Tyrosine-protein phosphatase non-receptor type

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt P29350
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

P29350
PTN6_HUMAN
Homo sapiens
Tyrosine-protein phosphatase non-receptor type 6

PDB Structure

PDB 2RMX
External Links
Method SOLUTION NMR
Organism
Primary Citation
Structural basis for the recognition of the two NKG2A immunoreceptor tyrosine-based inhibitory motifs (ITIMs) by the C-terminal SH2 domain of protein tyrosine phosphatase SHP-1
Koshiba, S., Kasai, T., Sato, M., Tomizawa, T., Motoda, Y., Tochio, N., Kobayashi, N., Harada, T., Inoue, M., Tanaka, A., Kigawa, T., Yokoyama, S.
To be Published
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