CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.1360
Functional Family Glucosamine-6-phosphate deaminase

Enzyme Information

3.5.99.6
Glucosamine-6-phosphate deaminase.
based on mapping to UniProt Q8DV70
Alpha-D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3).
-!- Isomerization of the aldose-ketose type converts the -CH(-NH(2))-CH=O group of glucosamine 6-phosphate into -C(=NH)-CH(2)-OH, forming 2-deoxy-2-imino-D-arabino-hexitol which then hydrolyzes to yield fructose 6-phosphate and ammonia. -!- N-acetyl-D-glucosamine 6-phosphate, which is not broken down, activates the enzyme. -!- Formerly EC 5.3.1.10.

UniProtKB Entries (1)

Q8DV70
NAGB_STRMU
Streptococcus mutans UA159
Glucosamine-6-phosphate deaminase

PDB Structure

PDB 2RI1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Ring-opening mechanism revealed by crystal structures of NagB and its ES intermediate complex
Liu, C., Li, D., Liang, Y.H., Li, L.F., Su, X.D.
J.Mol.Biol.