CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase

Enzyme Information

4.1.2.14
2-dehydro-3-deoxy-phosphogluconate aldolase.
based on mapping to UniProt Q704D1
2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.
-!- The enzyme shows no activity with 2-dehydro-3-deoxy-6-phosphate-D- galactonate (cf. EC 4.1.2.55). -!- Also acts on 2-oxobutanoate.
4.1.2.51
2-dehydro-3-deoxy-D-gluconate aldolase.
based on mapping to UniProt Q704D1
2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde.
-!- The enzyme from the archaeon Picrophilus torridus is involved in D-glucose and D-galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway. -!- In the direction of aldol synthesis the enzyme catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D- galactonate at a similar ratio. -!- It shows no activity with 2-dehydro-3-deoxy-D-gluconate 6-phosphate. -!- Cf. EC 4.1.2.14.

UniProtKB Entries (1)

Q704D1
KDGA_THETE
Thermoproteus tenax
2-dehydro-3-deoxy-D-gluconate/2-dehydro-3-deoxy-phosphogluconate aldolase

PDB Structure

PDB 2R91
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure and stereochemical studies of KD(P)G aldolase from Thermoproteus tenax.
Pauluhn, A., Ahmed, H., Lorentzen, E., Buchinger, S., Schomburg, D., Siebers, B., Pohl, E.
Proteins