CATH Classification

Domain Context

CATH Clusters

Superfamily 2.70.40.10
Functional Family dCTP deaminase, dUMP-forming

Enzyme Information

3.5.4.30
dCTP deaminase (dUMP-forming).
based on mapping to UniProt P9WP17
dCTP + 2 H(2)O = dUMP + diphosphate + NH(3).
-!- Is highly specific for dCTP as substrate as dCMP, CTP, CDP, CMP, cytosine or deoxycytosine are not deaminated. -!- While most bacteria require two enzymes to form dUMP from dCTP (EC 3.5.4.13 and EC 3.6.1.23), the archaeon Methanocaldococcus jannaschii uses a single enzyme to carry out both functions. -!- This enzyme can also act as a dUTP diphosphatase, but more slowly.

UniProtKB Entries (1)

P9WP17
DCDB_MYCTU
Mycobacterium tuberculosis H37Rv
DCTP deaminase, dUMP-forming

PDB Structure

PDB 2QXX
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Mechanism of dTTP inhibition of the bifunctional dCTP deaminase:dUTPase encoded by Mycobacterium tuberculosis.
Helt, S.S., Thymark, M., Harris, P., Aagaard, C., Dietrich, J., Larsen, S., Willemoes, M.
J.Mol.Biol.