CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.70 | Distorted Sandwich |
|
2.70.40 | Deoxyuridine 5'-Triphosphate Nucleotidohydrolase; Chain A |
|
2.70.40.10 | Deoxyuridine triphosphatase (dUTPase) |
Domain Context
CATH Clusters
| Superfamily | 2.70.40.10 |
| Functional Family | dCTP deaminase, dUMP-forming |
Enzyme Information
| 3.5.4.30 |
dCTP deaminase (dUMP-forming).
based on mapping to UniProt P9WP17
dCTP + 2 H(2)O = dUMP + diphosphate + NH(3).
-!- Is highly specific for dCTP as substrate as dCMP, CTP, CDP, CMP, cytosine or deoxycytosine are not deaminated. -!- While most bacteria require two enzymes to form dUMP from dCTP (EC 3.5.4.13 and EC 3.6.1.23), the archaeon Methanocaldococcus jannaschii uses a single enzyme to carry out both functions. -!- This enzyme can also act as a dUTP diphosphatase, but more slowly.
|
UniProtKB Entries (1)
| P9WP17 |
DCDB_MYCTU
Mycobacterium tuberculosis H37Rv
DCTP deaminase, dUMP-forming
|
PDB Structure
| PDB | 2QLP |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Mechanism of dTTP inhibition of the bifunctional dCTP
deaminase:dUTPase encoded by Mycobacterium tuberculosis
J.Mol.Biol.
|
