CATH Domain 2q1lC03

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.420	Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain

Superfamily	Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
Functional Family	3-hydroxy-3-methylglutaryl coenzyme A reductase

1.1.1.34

Hydroxymethylglutaryl-CoA reductase (NADPH).

based on mapping to UniProt P04035

(R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.

-!- The enzyme is inactivated by EC 2.7.11.31 and reactivated by EC 3.1.3.47.

HMDH_HUMAN

Homo sapiens

3-hydroxy-3-methylglutaryl-coenzyme A reductase

PDB	2Q1L
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors. Pfefferkorn, J.A., Song, Y., Sun, K.L., Miller, S.R., Trivedi, B.K., Choi, C., Sorenson, R.J., Bratton, L.D., Unangst, P.C., Larsen, S.D., Poel, T.J., Cheng, X.M., Lee, C., Erasga, N., Auerbach, B., Askew, V., Dillon, L., Hanselman, J.C., Lin, Z., Lu, G., Robertson, A., Olsen, K., Mertz, T., Sekerke, C., Pavlovsky, A., Harris, M.S., Bainbridge, G., Caspers, N., Chen, H., Eberstadt, M. Bioorg.Med.Chem.Lett.