CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Dihydroorotate dehydrogenase (quinone), mitochondrial

Enzyme Information
Dihydroorotate dehydrogenase (quinone).
based on mapping to UniProt Q02127
(S)-dihydroorotate + a quinone = orotate + a quinol.
-!- This Class 2 dihydroorotate dehydrogenase enzyme contains FMN. -!- The enzyme is found in eukaryotes in the mitochondrial membrane, in cyanobacteria, and in some Gram-negative and Gram-positive bacteria associated with the cytoplasmic membrane. -!- The reaction is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides. -!- The best quinone electron acceptors for the enzyme from bovine liver are ubiquinone-6 and ubiquinone-7, although simple quinones, such as benzoquinone, can also act as acceptor at lower rates. -!- Methyl-, ethyl-, tert-butyl and benzyl-(S)-dihydroorotates are also substrates, but methyl esters of (S)-1-methyl and (S)-3-methyl and (S)-1,3-dimethyldihydroorotates are not. -!- Class 1 dihydroorotate dehydrogenases use either fumarate (EC, NAD(+) (EC or NADP(+) (EC as electron acceptor. -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
Dihydroorotate dehydrogenase (quinone), mitochondrial

PDB Structure

External Links
Primary Citation
The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites
Walse, B., Dufe, V.T., Svensson, B., Fritzson, I., Dahlberg, L., Khairoullina, A., Wellmar, U., Al-Karadaghi, S.