CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.140 | Butyryl-CoA Dehydrogenase, subunit A; domain 3 |
|
1.20.140.20 | Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain |
Domain Context
CATH Clusters
| Superfamily | Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain |
| Functional Family | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial |
Enzyme Information
| 2.7.11.2 |
[Pyruvate dehydrogenase (acetyl-transferring)] kinase.
based on mapping to UniProt Q15120
ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.
-!- Has no activating compound but is specific for its substrate. -!- A mitochondrial enzyme associated with the pyruvate dehydrogenase complex in mammals. -!- Phosphorylation inactivates EC 1.2.4.1. -!- Formerly EC 2.7.1.99.
|
UniProtKB Entries (1)
| Q15120 |
PDK3_HUMAN
Homo sapiens
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial
|
PDB Structure
| PDB | 2PNR |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal Structure of an Asymmetric complex of Pyruvate Dehydrogenase
Kinase 3 with Lipoyl domain 2 and its Biological Implications
J.Mol.Biol.
|
