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CATH Classification

Domain Context

CATH Clusters

Superfamily 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Functional Family 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

Enzyme Information

4.6.1.12
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase.
based on mapping to UniProt Q9CAK8
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = 2-C-methyl- D-erythritol 2,4-cyclodiphosphate + CMP.
-!- Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.

UniProtKB Entries (1)

Q9CAK8
ISPF_ARATH
Arabidopsis thaliana
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, chloroplastic

PDB Structure

PDB 2PMP
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Biosynthesis of isoprenoids in plants: Structure of the 2C-methyl-D-erithrytol 2,4-cyclodiphosphate synthase from Arabidopsis thaliana. Comparison with the bacterial enzymes.
Calisto, B.M., Perez-Gil, J., Bergua, M., Querol-Audi, J., Fita, I., Imperial, S.
Protein Sci.
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