CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.25 | UDP-galactose 4-epimerase; domain 1 |
|
3.90.25.10 | UDP-galactose 4-epimerase, domain 1 |
Domain Context
CATH Clusters
| Superfamily | UDP-galactose 4-epimerase, domain 1 |
| Functional Family |
Enzyme Information
| 1.1.1.281 |
GDP-4-dehydro-6-deoxy-D-mannose reductase.
based on mapping to UniProt Q6T1X6
GDP-alpha-D-rhamnose + NAD(P)(+) = GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H.
-!- Differs from EC 1.1.1.187 in that the only product formed is GDP- alpha-D-rhamnose (GDP-6-deoxy-alpha-D-mannose). -!- D-rhamnose is a constituent of lipopolysaccharides of Gram-negative plant and human pathogenic bacteria.
|
UniProtKB Entries (1)
| Q6T1X6 |
RMD_ANETH
Aneurinibacillus thermoaerophilus
GDP-6-deoxy-D-mannose reductase
|
PDB Structure
| PDB | 2PK3 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The structural basis for catalytic function of GMD and RMD, two closely related enzymes from the GDP-D-rhamnose biosynthesis pathway.
Febs J.
|
