CATH Domain 2pfdB02

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.670	Formiminotransferase, C-terminal subdomain

Domain Context

CATH Clusters

Superfamily	Formiminotransferase, C-terminal subdomain
Functional Family	Formimidoyltransferase cyclodeaminase

Enzyme Information

4.3.1.4	Formimidoyltetrahydrofolate cyclodeaminase. based on mapping to UniProt O88618 5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH(3). -!- In eukaroytes, occurs as a bifunctional enzyme that also has EC 2.1.2.5 activity.
2.1.2.5	Glutamate formimidoyltransferase. based on mapping to UniProt O88618 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate. -!- In eukaryotes occurs as a bifunctional enzyme also having EC 4.3.1.4 activity. -!- Formerly EC 2.1.2.6.

UniProtKB Entries (1)

FTCD_RAT

Rattus norvegicus

Formimidoyltransferase-cyclodeaminase

PDB Structure

PDB	2PFD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Anisotropically refined structure of FTCD Poon, B.K., Chen, X., Lu, M., Vyas, N.K., Quiocho, F.A., Wang, Q., Ma, J. To be Published