CATH Domain 2p4dA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.190	Protein-Tyrosine Phosphatase; Chain A
	3.90.190.10	Protein tyrosine phosphatase superfamily

Domain Context

CATH Clusters

Superfamily	Protein tyrosine phosphatase superfamily
Functional Family

Enzyme Information

3.1.3.-	Phosphoric monoester hydrolases. based on mapping to UniProt P33064
3.1.3.48	Protein-tyrosine-phosphatase. based on mapping to UniProt P33064 Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. -!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

DUSP_VAR67

Variola virus human/India/Ind3/1967

Dual specificity protein phosphatase H1

PDB Structure

PDB	2P4D
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure-assisted discovery of variola major H1 phosphatase inhibitors Phan, J., Tropea, J.E., Waugh, D.S. Acta Crystallogr.,Sect.D