CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome c-like domain
Functional Family L-cysteine S-thiosulfotransferase subunit SoxA

Enzyme Information
L-cysteine S-thiosulfotransferase.
based on mapping to UniProt Q939U1
(1) [SoxY protein]-L-cysteine + thiosulfate + 2 ferricytochrome c = [SoxY protein]-S-sulfosulfanyl-L-cysteine + 2 ferrocytochrome c + 2 H(+). (2) [SoxY protein]-S-sulfanyl-L-cysteine + thiosulfate + 2 ferricytochrome c = [SoxY protein]-S-(2-sulfodisulfanyl)-L-cysteine + 2 ferrocytochrome c + 2 H(+).
-!- The enzyme is part of the Sox enzyme system, which participates in a bacterial thiosulfate oxidation pathway that produces sulfate. -!- It catalyzes two reactions in the pathway - early in the pathway it attaches a thiosulfate molecule to the sulfur atom of an L-cysteine of a SoxY protein; later it transfers a second thiosulfate molecule to a sulfane group that is already attached to the same cysteine residue.

UniProtKB Entries (1)

Rhodovulum sulfidophilum
L-cysteine S-thiosulfotransferase subunit SoxA

PDB Structure

External Links
Organism Rhodobacter
Primary Citation
The crystal structure of recombinant Rhodovulum sulfidophilum SoxAX confirms cysteine persulfide coordination to the catalytic heme
Kihlken, M.A., Berks, B.C., Hemmings, A.M.
To be Published