CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1220 | TPP-binding domain |
Domain Context
CATH Clusters
| Superfamily | TPP-binding domain |
| Functional Family |
Enzyme Information
| 7.1.1.1 |
Proton-translocating NAD(P)(+) transhydrogenase.
based on mapping to UniProt P0C188
NADPH + NAD(+) + H(+)(Side 1) = NADP(+) + H(+)(Side 2) + NADH.
-!- The enzyme is a membrane bound proton-translocating pyridine nucleotide transhydrogenase that couples the reversible reduction of NADP by NADH to an inward proton translocation across the membrane. -!- In the bacterium Escherichia coli the enzyme provides a major source of cytosolic NADPH. -!- Detoxification of reactive oxygen species in mitochondria by glutathione peroxidases depends on NADPH produced by this enzyme. -!- Formerly EC 1.6.1.5.
|
UniProtKB Entries (2)
| Q2RSB2 |
PNTAA_RHORT
Rhodospirillum rubrum ATCC 11170
NAD(P) transhydrogenase subunit alpha part 1
|
| P0C188 |
PNTB_RHORU
Rhodospirillum rubrum
NAD(P) transhydrogenase subunit beta
|
PDB Structure
| PDB | 2OOR |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structures of the dI(2)dIII(1) Complex of Proton-Translocating Transhydrogenase with Bound, Inactive Analogues of NADH and NADPH Reveal Active Site Geometries
Biochemistry
|