CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family NAD(P) transhydrogenase alpha subunit 1

Enzyme Information

7.1.1.1
Proton-translocating NAD(P)(+) transhydrogenase.
based on mapping to UniProt Q2RSB2
NADPH + NAD(+) + H(+)(Side 1) = NADP(+) + H(+)(Side 2) + NADH.
-!- The enzyme is a membrane bound proton-translocating pyridine nucleotide transhydrogenase that couples the reversible reduction of NADP by NADH to an inward proton translocation across the membrane. -!- In the bacterium Escherichia coli the enzyme provides a major source of cytosolic NADPH. -!- Detoxification of reactive oxygen species in mitochondria by glutathione peroxidases depends on NADPH produced by this enzyme. -!- Formerly EC 1.6.1.5.

UniProtKB Entries (2)

Q2RSB2
PNTAA_RHORT
Rhodospirillum rubrum ATCC 11170
NAD(P) transhydrogenase subunit alpha part 1
P0C188
PNTB_RHORU
Rhodospirillum rubrum
NAD(P) transhydrogenase subunit beta

PDB Structure

PDB 2OO5
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structures of the dI(2)dIII(1) Complex of Proton-Translocating Transhydrogenase with Bound, Inactive Analogues of NADH and NADPH Reveal Active Site Geometries
Bhakta, T., Whitehead, S.J., Snaith, J.S., Dafforn, T.R., Wilkie, J., Rajesh, S., White, S.A., Jackson, J.B.
Biochemistry