CATH Classification

Domain Context

CATH Clusters

Superfamily Cyclophilin-like
Functional Family Peptidyl-prolyl cis-trans isomerase

Enzyme Information
Peptidylprolyl isomerase.
based on mapping to UniProt Q9H2H8
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Homo sapiens
Peptidyl-prolyl cis-trans isomerase-like 3

PDB Structure

External Links
Primary Citation
Targeting Cyclophilin J, a Novel Peptidyl-Prolyl Isomerase, Can Induce Cellular G1/S Arrest and Repress the Growth of Hepatocellular Carcinoma
Chen, J., Chen, S., Huang, L., Zhao, X., Tan, J., Huang, C., Saiyin, H., Zhang, M., Zeng, X., Xi, J., Wan, B., Zhao, Y., Xia, Z., Jiang, H., Yi, Q., Liu, J.O., Yu, L.
To be Published