CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.300.10
Functional Family

Enzyme Information

2.5.1.6
Methionine adenosyltransferase.
based on mapping to UniProt Q00266
ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L- methionine.
-!- Formerly EC 2.4.2.13.

UniProtKB Entries (1)

Q00266
METK1_HUMAN
Homo sapiens
S-adenosylmethionine synthase isoform type-1

PDB Structure

PDB 2OBV
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with the product.
Pilka, E.S., Shafqat, N., Kavanagh, K.L., Cooper, C., Hozjan, V., Turnbull, A., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
To be Published