CATH Classification

Domain Context

CATH Clusters

Superfamily Fumarase/aspartase (Central domain)
Functional Family Tyrosine ammonia-lyase

Enzyme Information

4.3.1.23
Tyrosine ammonia-lyase.
based on mapping to UniProt Q3IWB0
L-tyrosine = trans-p-hydroxycinnamate + ammonia.
-!- Member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.3, EC 4.3.1.24 and EC 4.3.1.25. -!- Far more active with tyrosine than with phenylalanine as substrate, but the substrate specificity can be switched by mutation of a single amino acid (H89F) in the enzyme from the bacterium Rhodobacter sphaeroides. -!- Formerly EC 4.3.1.5.

UniProtKB Entries (1)

Q3IWB0
TALY_RHOS4
Rhodobacter sphaeroides 2.4.1
Tyrosine ammonia-lyase

PDB Structure

PDB 2O78
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases.
Louie, G.V., Bowman, M.E., Moffitt, M.C., Baiga, T.J., Moore, B.S., Noel, J.P.
Chem.Biol.