CATH Domain 2nvuB05

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.290	Structural Genomics Hypothetical 15.5 Kd Protein In mrcA-pckA Intergenic Region; Chain A
	3.10.290.20	Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3

Domain Context

CATH Clusters

Superfamily	Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3
Functional Family	NEDD8-activating enzyme E1 catalytic subunit, variant

Enzyme Information

6.2.1.-

Acid--thiol ligases.

based on mapping to UniProt Q8TBC4

UniProtKB Entries (1)

ULA1_HUMAN

Homo sapiens

NEDD8-activating enzyme E1 regulatory subunit

PDB Structure

PDB	2NVU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity. Huang, D.T., Hunt, H.W., Zhuang, M., Ohi, M.D., Holton, J.M., Schulman, B.A. Nature