CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family Calpain-1 catalytic subunit

Enzyme Information

3.4.22.52
Calpain-1.
based on mapping to UniProt P97571
Broad endopeptidase specificity.
-!- Cytosolic in animal cells. -!- The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.53. -!- Belongs to peptidase family C2. -!- Formerly EC 3.4.22.17 and EC 3.4.24.5.

UniProtKB Entries (1)

P97571
CAN1_RAT
Rattus norvegicus
Calpain-1 catalytic subunit

PDB Structure

PDB 2NQI
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Development of Calpain-specific Inactivators by Screening of Positional Scanning Epoxide Libraries
Cuerrier, D., Moldoveanu, T., Campbell, R.L., Kelly, J., Yoruk, B., Verhelst, S.H.L., Greenbaum, D., Bogyo, M., Davies, P.L.
J.Biol.Chem.