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1 keywords

CATH Domain 2m2fA00

CATH Classification

Level CATH Code Description
Class 4 Few Secondary Structures
Architecture 4.10 Irregular
Topology 4.10.70 Echistatin
Homologous Superfamily 4.10.70.30  

Domain Context

CATH Clusters

Superfamily 4.10.70.30
Functional Family Disintegrin and metalloproteinase domain-containing protein 17

Enzyme Information

3.4.24.86
ADAM 17 endopeptidase.
based on mapping to UniProt P78536
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val- Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other membrane-anchored, cell-surface proteins to 'shed' the extracellular domains.
-!- In vivo, the cleavage of tumor necrosis factor alpha precursor releases the soluble, 17-kDa TNF-alpha, which induces inflammation. -!- Belongs to peptidase family M12.

UniProtKB Entries (1)

P78536
ADA17_HUMAN
Homo sapiens
Disintegrin and metalloproteinase domain-containing protein 17

PDB Structure

PDB 2M2F
External Links
Method SOLUTION NMR
Organism
Primary Citation
Membrane-proximal domain of a disintegrin and metalloprotease-17 represents the putative molecular switch of its shedding activity operated by protein-disulfide isomerase.
Dusterhoft, S., Jung, S., Hung, C.W., Tholey, A., Sonnichsen, F.D., Grotzinger, J., Lorenzen, I.
J.Am.Chem.Soc.
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