CATH Domain 2m1cA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.450	Beta-Lactamase
	3.30.450.20	PAS domain

Domain Context

CATH Clusters

Superfamily	PAS domain
Functional Family

Enzyme Information

3.1.4.59

Cyclic-di-AMP phosphodiesterase.

based on mapping to UniProt A4ITV2

Cyclic di-3',5'-adenylate + H(2)O = 5'-O-phosphonoadenylyl-(3'->5')- adenosine.

-!- The enzyme, described from Gram-positive bacteria, degrades the second messenger cyclic di-3',5'-adenylate. -!- It is a membrane-bound protein that contains a cytoplasmic facing Per-Arnt-Sim (PAS) domain, a modified GGDEF domain, and a DHH/DHHA1 domain, which confers the phosphodiesterase activity. -!- Activity requires Mn(2+) and is inhibited by pApA.

UniProtKB Entries (1)

A4ITV2

GDPP_GEOTN

Geobacillus thermodenitrificans NG80-2

Cyclic-di-AMP phosphodiesterase GdpP

PDB Structure

PDB	2M1C
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	Solution Structure of the PAS Domain of a Thermophilic YybT Protein Homolog Reveals a Potential Ligand-binding Site. Tan, E., Rao, F., Pasunooti, S., Pham, T.H., Soehano, I., Turner, M.S., Liew, C.W., Lescar, J., Pervushin, K., Liang, Z.X. J.Biol.Chem.

Network disruptions